Rasmus Eide (armok) says:

Obviously, if nick became a wearwolf, he'd shrink down to just a few decimetres in length and grow two more rotors. (yea, I just googled "wolf helicopter")

 

Seriously thou, a realistic solution would be that a wolf got into the plumbing somehow, and bit one of the dialysis machines or blood oxygenating apparatus you realistically need to keep a disembodied brain alive for longer than a few hours outside the body. These, while most likely kept fairly close to each other to minimize the amount of needed blood and such, are a much larger target than just the brain, as well as most likely less protected. More importantly however, is that there is almost certainly some degree of redundancy (most likely a triple redundancy; 2/3 of the equipment can fail and he's still alive), meaning that while a wolf bite would probably ruin the specific piece of machinery it happened to, it would not be a mortal wound, and the virus would probably quite easily escape to contaminate all the systems, as well as the brain.

As for the effects, realistically the non-biological parts of him would be unaffected, which is the majority, but the behavioural consequences would still be more than enough to make is justified, especially considering he presumably have a lot of weapons that have so far been mostly irrelevant due to his pacifism that prevents him from using them,to the point of both readers and characters almost forgetting about them.

 All considered, an infection of nick would have several storytelling uses:

- It makes it possible to elaborate most on both the exact configuration of nick biologically, as well as how the virus would affect something it's creator had not intended (he probably foresaw both humans and canines getting infected, but what happens if it tries it's morphology magic on something that's genetically human, but has gotten what is basically a full body amputation. How does the virus pull of such quick and massive morphological change in general?), I know technically Unity has been infected as well but she's biochemically different enough to be immune, so we didn't get to see that much at all.

- We get to see a massive berserk helicopter blowing stuff up.

- Character development for nick, once he is restored facing the fact that he killed a lot of people (even if they were wearwolves, and he was robed of his free will by a virus) might lead to some very interesting things. Would he go all angsty, or yet again show of his apathetic and logical side shrugging it of?

 

 

This is not a suggestion really, after all this arc is probably already planed out, and at least this point seems to be according to the above, this is more of a "what if" kind of thing to make the authors think "why didn't we think of that before it was to late!", thou it's probably to realistic and dark and serious for the style of Skin Horse anyway.